Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular
September 11, 2020
Bettering the Efficacy of Tumor Radiosensitization By means of Mixed Molecular Focusing on
Chemoradiation, both alone or together with surgical procedure or induction chemotherapy, is the present customary of care for many domestically superior strong tumors. Although chemoradiation is normally carried out on the most tolerated doses of each chemotherapy and radiation, present remedy charges usually are not passable for a lot of tumor entities, since tumor heterogeneity and plasticity end in chemo- and radioresistance.
Advances within the understanding of tumor biology, a quickly rising variety of molecular concentrating on brokers and novel applied sciences enabling the in-depth characterization of particular person tumors, have fuelled the hope of getting into an period of precision oncology, the place every tumor will be handled in keeping with its particular person traits and weaknesses.
At current although, molecular concentrating on approaches together with radiotherapy or chemoradiation haven’t but confirmed to be useful over customary chemoradiation remedy within the medical setting. A promising strategy to enhance efficacy is the mixed utilization of two concentrating on brokers to be able to inhibit backup pathways or obtain a extra full pathway inhibition. Right here we evaluation preclinical makes an attempt to make the most of such twin concentrating on methods for future tumor radiosensitization
Agarose, low EEO |
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GE0001-100 | Glentham Life Sciences | 100 | EUR 102.7 |
Agarose, low EEO |
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GE0001-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
Agarose, low EEO |
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GE0001-1KG | Glentham Life Sciences | 1 kg | EUR 724.8 |
Agarose, low EEO |
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GE0001-25 | Glentham Life Sciences | 25 | EUR 39.4 |
Agarose, low EEO |
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GE0001-250 | Glentham Life Sciences | 250 | EUR 189.8 |
Agarose, low EEO |
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GE0001-250G | Glentham Life Sciences | 250 g | EUR 265.2 |
Agarose, low EEO |
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GE0001-25G | Glentham Life Sciences | 25 g | EUR 84 |
Agarose, low EEO |
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GE0001-5 | Glentham Life Sciences | 5 | EUR 19 |
Agarose, low EEO |
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GE0001-500 | Glentham Life Sciences | 500 | EUR 316.4 |
Agarose, low EEO |
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GE0001-500G | Glentham Life Sciences | 500 g | EUR 418.8 |
Agarose, low EEO |
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GE0001-5G | Glentham Life Sciences | 5 g | EUR 58.8 |
Agarose Low EEO |
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abx299901-100g | Abbexa | 100 µg | EUR 425 |
Agarose Low EEO |
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abx299901-20g | Abbexa | 20 µg | EUR 300 |
Agarose Low EEO |
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abx299901-50g | Abbexa | 50 µg | EUR 350 |
Agarose, Low Melting |
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RM861-100G | EWC Diagnostics | 1 unit | EUR 533.55 |
Description: Agarose, Low Melting |
Agarose, Low Melting |
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RM861-10G | EWC Diagnostics | 1 unit | EUR 57.22 |
Description: Agarose, Low Melting |
Agarose, Low Melting |
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RM861-25G | EWC Diagnostics | 1 unit | EUR 125.79 |
Description: Agarose, Low Melting |
Agarose LE Low EEO |
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AXY1002 | Scientific Laboratory Supplies | PK10 | EUR 5152.05 |
Agarose B, Low EEO |
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AB0014 | Bio Basic | 50g | EUR 99.67 |
AGAROSE, LOW GEL TEMP |
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A1315 | PhytoTechnology Laboratories | 25G | EUR 201.28 |
Agarose LM Low Melting |
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AXY1006 | Scientific Laboratory Supplies | PK10 | EUR 3480.06 |
AGAROSE, LOW MELT POINT |
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IB70056 | IBI Scientific | 100GM | EUR 377.98 |
AGAROSE, LOW MELT POINT |
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IB70057 | IBI Scientific | 250GM | EUR 924.25 |
AGAROSE, LOW MELT POINT |
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IB70058 | IBI Scientific | 500GM | EUR 1768.48 |
AGAROSE, LOW MELT POINT |
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IB70059 | IBI Scientific | 1KG | EUR 3156.47 |
AGAROSE, LOW MELT POINT |
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IB70050 | IBI Scientific | 50GM | EUR 254.65 |
AGAROSE, LOW MELT POINT |
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IB70051 | IBI Scientific | 25GM | EUR 115.63 |
Agarose, Low melting gel |
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AB0015 | Bio Basic | 10g | EUR 96.54 |
Agarose, Low Melt Temperature |
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40100156-1 | Glycomatrix | 10 g | EUR 68.53 |
Agarose, Low Melt Temperature |
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40100156-2 | Glycomatrix | 25 g | EUR 136.81 |
Agarose, Low Melt Temperature |
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40100156-3 | Glycomatrix | 50 g | EUR 258.28 |
Agarose, Low Melt Temperature |
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40100156-4 | Glycomatrix | 100 g | EUR 466.78 |
Agarose LE Low EEO - PK10 |
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AXY1000 | Scientific Laboratory Supplies | PK10 | EUR 2560.95 |
Apex Low Melt Agarose |
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20-103 | Genesee Scientific | 25g/Unit | EUR 126.76 |
Description: Ultra Pure |
Apex Low Melt Agarose |
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20-104 | Genesee Scientific | 100g/Unit | EUR 392.66 |
Description: Ultra Pure |
Agarose, Low Gelling Temperature |
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40100124-1 | Glycomatrix | 25 g | EUR 243.29 |
Agarose special, Low EEO |
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MB002-100G | EWC Diagnostics | 1 unit | EUR 38.61 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-10G | EWC Diagnostics | 1 unit | EUR 6.93 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-1KG | EWC Diagnostics | 1 unit | EUR 333.43 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-500G | EWC Diagnostics | 1 unit | EUR 185.23 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-50G | EWC Diagnostics | 1 unit | EUR 21.45 |
Description: Agarose special, Low EEO |
Agarose, special, Low EEO |
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RM273-100G | EWC Diagnostics | 1 unit | EUR 71.82 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-10G | EWC Diagnostics | 1 unit | EUR 11.64 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-25G | EWC Diagnostics | 1 unit | EUR 22.45 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-500G | EWC Diagnostics | 1 unit | EUR 374.99 |
Description: Agarose, special, Low EEO |
Agarose LM Low Melting - PK10 |
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AXY1004 | Scientific Laboratory Supplies | PK10 | EUR 12779.1 |
HiQTM Low Melting Agarose |
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A0223-002 | GenDepot | 25g | EUR 343.2 |
HiQTM Low Melting Agarose |
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A0223-010 | GenDepot | 100g | EUR 699.6 |
Agarose, Ultrapure, Low EEO |
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MB229-100G | EWC Diagnostics | 1 unit | EUR 110.64 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-1KG | EWC Diagnostics | 1 unit | EUR 707.74 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-500G | EWC Diagnostics | 1 unit | EUR 442.58 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-50G | EWC Diagnostics | 1 unit | EUR 58.16 |
Description: Agarose, Ultrapure, Low EEO |
Agarose GPG/LMP low melt |
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A2501-100000 | ApexBio | 100 g | EUR 510 |
Description: Agarose has a wide range of physical, chemical and thermal stability, because of its greatest gelling ability that it acquires wide applications in biotechnology [2], such as agarose gel electrophoresis, protein purification, solid culture media, motility assays. |
Agarose GPG/LMP low melt |
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A2501-25000 | ApexBio | 25 g | EUR 184.8 |
Description: Agarose has a wide range of physical, chemical and thermal stability, because of its greatest gelling ability that it acquires wide applications in biotechnology [2], such as agarose gel electrophoresis, protein purification, solid culture media, motility assays. |
Agarose II, Low Gelling Temperature |
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CH002 | ABM | 25 g | EUR 274.8 |
Agarose II, Low Gelling Temperature |
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CH003 | ABM | 100 g | EUR 350 |
Apex Low Melt Sieve Agarose |
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20-245 | Genesee Scientific | 100g/Unit | EUR 304.36 |
Description: Ultra Pure |
Benchmark Agarose LM, Low Melt, 100g |
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A1801-LM | Benchmark Scientific | 1 PC | EUR 388.41 |
HyAgarose? LM Agarose, Low Melting, 100g |
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R9012LM-100g | ACTGene | each | EUR 452.4 |
HyAgarose? LM Agarose, Low Melting, 10g |
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R9012LM-10g | ACTGene | each | EUR 120 |
HyAgarose? LM Agarose, Low Melting, 500g |
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R9012LM-500g | ACTGene | each | EUR 1821.6 |
HyAgarose? LM Agarose, Low Melting, 50g |
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R9012LM-50g | ACTGene | each | EUR 262.8 |
HyAgarose™ LM Agarose, Low Melting, 10g |
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R9012LM | ACTGene | 10g | EUR 43.98 |
Low Density Glyoxal Agarose Beads (4%) |
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abx291309-100g | Abbexa | 100 µg | Ask for price |
Low Density Glyoxal Agarose Beads (4%) |
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abx291309-20g | Abbexa | 20 µg | EUR 275 |
Low Density Glyoxal Agarose Beads (4%) |
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abx291309-50g | Abbexa | 50 µg | EUR 650 |
Low Density Glyoxal Agarose Beads (6%) |
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abx291312-100g | Abbexa | 100 µg | Ask for price |
Low Density Glyoxal Agarose Beads (6%) |
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abx291312-20g | Abbexa | 20 µg | EUR 275 |
Low Density Glyoxal Agarose Beads (6%) |
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abx291312-50g | Abbexa | 50 µg | EUR 650 |
Low Density Aminoethyl Agarose Beads (6%) |
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abx291321-100g | Abbexa | 100 µg | Ask for price |
Low Density Aminoethyl Agarose Beads (6%) |
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abx291321-20g | Abbexa | 20 µg | EUR 312.5 |
Low Density Aminoethyl Agarose Beads (6%) |
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abx291321-50g | Abbexa | 50 µg | EUR 662.5 |
Low Density Glyoxal Fine Agarose Beads (4%) |
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abx291311-100g | Abbexa | 100 µg | Ask for price |
Low Density Glyoxal Fine Agarose Beads (4%) |
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abx291311-20g | Abbexa | 20 µg | EUR 337.5 |
Low Density Glyoxal Fine Agarose Beads (4%) |
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abx291311-50g | Abbexa | 50 µg | EUR 850 |
Low Density Glyoxal Fine Agarose Beads (6%) |
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abx291314-100g | Abbexa | 100 µg | Ask for price |
Low Density Glyoxal Fine Agarose Beads (6%) |
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abx291314-20g | Abbexa | 20 µg | EUR 337.5 |
Low Density Glyoxal Fine Agarose Beads (6%) |
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abx291314-50g | Abbexa | 50 µg | EUR 850 |
Very Low Density Aminoethyl Agarose Beads (4%) |
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abx291319-100g | Abbexa | 100 µg | Ask for price |
Very Low Density Aminoethyl Agarose Beads (4%) |
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abx291319-20g | Abbexa | 20 µg | EUR 312.5 |
Very Low Density Aminoethyl Agarose Beads (4%) |
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abx291319-50g | Abbexa | 50 µg | EUR 662.5 |
Agarose, low EEO, GlenBiol, suitable for molecular biology |
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GE6258-100G | Glentham Life Sciences | 100 g | EUR 217.2 |
Very Low Density Aminoethyl Fine Agarose Beads (6%) |
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abx291323-100g | Abbexa | 100 µg | Ask for price |
Very Low Density Aminoethyl Fine Agarose Beads (6%) |
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abx291323-20g | Abbexa | 20 µg | EUR 337.5 |
Very Low Density Aminoethyl Fine Agarose Beads (6%) |
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abx291323-50g | Abbexa | 50 µg | EUR 712.5 |
Agarose, low EEO, GlenBiol™, suitable for molecular biology |
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GE6258-100 | Glentham Life Sciences | 100 | EUR 150.4 |
Agarose, low EEO, GlenBiol™, suitable for molecular biology |
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GE6258-25 | Glentham Life Sciences | 25 | EUR 60.1 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT |
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AGR-LE-100 | CORNING | 1/pk | EUR 201.6 |
Description: Bioscience Mol Bio; Agarose |
Agarose |
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G060-1 | ABM | 100 g | EUR 185 |
Description: Agarose, derived from agar, is a polymeric cross-linked polysaccharide that is mainly used in gel electrophoresis. The lattice bonds formed in the gel allow proteins of different sizes to travel at different speeds down the gel. |
Agarose |
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G060-2 | ABM | 500 g | EUR 415 |
Description: Agarose, derived from agar, is a polymeric cross-linked polysaccharide that is mainly used in gel electrophoresis. The lattice bonds formed in the gel allow proteins of different sizes to travel at different speeds down the gel. |
Agarose |
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A12140 | Pfaltz & Bauer | 5G | EUR 113.97 |
Agarose |
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20-abx098147 | Abbexa |
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Agarose |
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20-abx186369 | Abbexa |
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Agarose |
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abx082006-100g | Abbexa | 100 g | EUR 292.8 |
Agarose |
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abx082007-100g | Abbexa | 100 g | EUR 309.6 |
Agarose |
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abx082008-100g | Abbexa | 100 g | EUR 276 |
AGAROSE |
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IB70035 | IBI Scientific | 25GM | EUR 48.47 |
AGAROSE |
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IB70040 | IBI Scientific | 100GM | EUR 144.84 |
AGAROSE |
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IB70041 | IBI Scientific | 250GM | EUR 271 |
AGAROSE |
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IB70042 | IBI Scientific | 500GM | EUR 476.49 |
AGAROSE |
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IB70045 | IBI Scientific | 1KG | EUR 816.44 |
AGAROSE |
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IB70046 | IBI Scientific | 2.5KG | EUR 2162.07 |
AGAROSE |
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IB70047 | IBI Scientific | 5KG | EUR 3780.9 |
Agarose |
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MB080-100G | EWC Diagnostics | 1 unit | EUR 533.09 |
Description: Agarose |
Agarose |
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MB080-10G | EWC Diagnostics | 1 unit | EUR 59.42 |
Description: Agarose |
Agarose |
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MB094-100G | EWC Diagnostics | 1 unit | EUR 55.96 |
Description: Agarose |
Agarose |
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MB094-1KG | EWC Diagnostics | 1 unit | EUR 894.45 |
Description: Agarose |
Agarose |
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MB094-500G | EWC Diagnostics | 1 unit | EUR 223.32 |
Description: Agarose |
Agarose |
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Z5050007 | Biochain | 500 g | EUR 575 |
Agarose |
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Z5050013 | Biochain | 100 g | EUR 141 |
Agarose |
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abx299902-100g | Abbexa | 100 µg | EUR 350 |
Agarose |
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abx299902-20g | Abbexa | 20 µg | EUR 262.5 |
Agarose |
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abx299902-50g | Abbexa | 50 µg | EUR 287.5 |
Agarose |
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abx098147-100l | Abbexa | 100 µl | EUR 262.5 |
Agarose |
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abx098147-1ml | Abbexa | 1 ml | Ask for price |
Agarose |
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abx098147-200l | Abbexa | 200 µl | Ask for price |
Agarose |
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abx461004-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Agarose |
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abx461004-596tests | Abbexa | 5 × 96 tests | EUR 850 |
Agarose |
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abx461004-96tests | Abbexa | 96 tests | EUR 425 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 500G/UNIT, 10 UNITS PER CASE |
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AGR-LE-5001 | CORNING | 1/pk | EUR 3669.6 |
Description: Bioscience Mol Bio; Agarose |
Agarose (3%) & LE Agarose 1% in 1X TAE Buffer |
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40120844-1 | Glycomatrix | 100 mL | EUR 33.86 |
Agarose (3%) & LE Agarose 1% in 1X TAE Buffer |
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40120844-2 | Glycomatrix | 250 mL | EUR 53.99 |
Agarose (3%) & LE Agarose 1% in 1X TAE Buffer |
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40120844-3 | Glycomatrix | 500 mL | EUR 81.44 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT, 10 UNITS PER CASE |
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AGR-LE-1001 | CORNING | 1/pk | EUR 926.4 |
Description: Bioscience Mol Bio; Agarose |
Agarose -LE |
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01132-34 | NACALAI TESQUE | 100G | EUR 124.6 |
Agarose -LE |
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01132-92 | NACALAI TESQUE | 25G | EUR 44.8 |
Agarose -ME |
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01133-24 | NACALAI TESQUE | 100G | EUR 122.5 |
Agarose -ME |
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01133-82 | NACALAI TESQUE | 25G | EUR 44.1 |
Agarose -HE |
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01134-14 | NACALAI TESQUE | 100G | EUR 122.5 |
Agarose I |
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40100104-1 | Glycomatrix | 25 g | EUR 31.11 |
Agarose I |
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40100104-2 | Glycomatrix | 100 g | EUR 78.67 |
Agarose I |
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40100104-3 | Glycomatrix | 250 g | EUR 171.95 |
Agarose I |
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40100104-4 | Glycomatrix | 500 g | EUR 288.65 |
Agarose I |
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40100104-5 | Glycomatrix | 1 kg | EUR 483.16 |
Agarose A |
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D0012 | Bio Basic | 50g | EUR 96.54 |
Agarose M |
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AB0013 | Bio Basic | 50g | EUR 91.32 |
Agarose LE |
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A-1270-100 | ABTBeads | 100 g | EUR 139.2 |
Agarose LE |
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A-1270-500 | ABTBeads | 500 g | EUR 349.2 |
Agarose HR |
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A-1280-100 | ABTBeads | 100 g | EUR 219.6 |
Agarose HR |
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A-1280-500 | ABTBeads | 500 g | EUR 822 |
Agarose GA |
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A-1290-100 | ABTBeads | 100 g | EUR 123.6 |
Agarose GA |
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A-1290-500 | ABTBeads | 500 g | EUR 306 |
Agarose LM |
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A-1300-100 | ABTBeads | 100 g | EUR 230.4 |
Agarose LM |
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A-1300-25 | ABTBeads | 25 g | EUR 123.6 |
Agarose L.M.P |
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20-abx082386 | Abbexa |
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LE Agarose |
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PCR-269L | Jena Bioscience GmbH | 2 x 500g | EUR 808.2 |
LE Agarose |
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PCR-269S | Jena Bioscience GmbH | 2 x 100g | EUR 202 |
LM Agarose |
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PCR-277L | Jena Bioscience GmbH | 5 x 50g | EUR 890 |
LM Agarose |
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PCR-277S | Jena Bioscience GmbH | 50g | EUR 222.5 |
AGAROSE, P.F.G.E. |
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IB70060 | IBI Scientific | 25GM | EUR 41.75 |
AGAROSE, P.F.G.E. |
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IB70061 | IBI Scientific | 50GM | EUR 58.73 |
AGAROSE, P.F.G.E. |
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IB70062 | IBI Scientific | 100GM | EUR 104.39 |
AGAROSE, P.F.G.E. |
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IB70063 | IBI Scientific | 250GM | EUR 252.05 |
AGAROSE, P.F.G.E. |
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IB70064 | IBI Scientific | 500GM | EUR 498.97 |
AGAROSE, P.F.G.E. |
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IB70065 | IBI Scientific | 1KG | EUR 956.47 |
Agarose L.M.P |
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abx082386-100l | Abbexa | 100 µl | EUR 175 |
Agarose L.M.P |
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abx082386-1ml | Abbexa | 1 ml | Ask for price |
Agarose L.M.P |
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abx082386-200l | Abbexa | 200 µl | EUR 375 |
8% B Agarose Bead Standard (50-150 µm) |
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A-1080S-1000 | ABTBeads | 1 l | EUR 607.2 |
8% B Agarose Bead Standard (50-150 µm) |
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A-1080S-10000 | ABTBeads | 10 l | Ask for price |
8% B Agarose Bead Standard (50-150 µm) |
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A-1080S-500 | ABTBeads | 500 ml | EUR 355.2 |
B Agarose Bead Standard (50-150 µm) (8%) |
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abx291350-100g | Abbexa | 100 µg | Ask for price |
B Agarose Bead Standard (50-150 µm) (8%) |
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abx291350-20g | Abbexa | 20 µg | EUR 537.5 |
B Agarose Bead Standard (50-150 µm) (8%) |
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abx291350-50g | Abbexa | 50 µg | EUR 887.5 |
Agarose -LGT |
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01136-52 | NACALAI TESQUE | 25G | EUR 115.5 |
Agarose -LGT |
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01136-94 | NACALAI TESQUE | 100G | EUR 329 |
Agarose -HGT |
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01137-84 | NACALAI TESQUE | 100G | EUR 122.5 |
Agarose -HGS |
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01143-52 | NACALAI TESQUE | 25G | EUR 49 |
Agarose -HGS |
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01143-94 | NACALAI TESQUE | 100G | EUR 133 |
8% BCL Agarose Bead Standard (50-150 µm) |
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A-1081S-1000 | ABTBeads | 1 l | EUR 681.6 |
8% BCL Agarose Bead Standard (50-150 µm) |
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A-1081S-10000 | ABTBeads | 10 l | Ask for price |
8% BCL Agarose Bead Standard (50-150 µm) |
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A-1081S-500 | ABTBeads | 500 ml | EUR 381.6 |
BCL Agarose Bead Standard (50-150 µm) (8%) |
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abx291355-100g | Abbexa | 100 µg | Ask for price |
BCL Agarose Bead Standard (50-150 µm) (8%) |
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abx291355-20g | Abbexa | 20 µg | EUR 575 |
BCL Agarose Bead Standard (50-150 µm) (8%) |
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abx291355-50g | Abbexa | 50 µg | EUR 987.5 |
AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE (AL) |
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AGR-LM-1001 | CORNING | 1/pk | EUR 4484.4 |
Description: Bioscience Mol Bio; Agarose |
AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 50G/UNIT, 10 UNITS PER CASE (AL) |
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AGR-LM-501 | CORNING | 1/pk | EUR 2490 |
Description: Bioscience Mol Bio; Agarose |
Agarose (blank) |
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AC-001L | Jena Bioscience GmbH | 5ml | EUR 266 |
Agarose (blank) |
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AC-001S | Jena Bioscience GmbH | 1ml | EUR 68.9 |
Agarose, Sepro |
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A0224-010 | GenDepot | 100g | EUR 262.8 |
Agarose, Sepro |
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A0224-020 | GenDepot | 200g | EUR 343.2 |
Agarose, Sepro |
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A0224-050 | GenDepot | 500g | EUR 522 |
Biotin Agarose |
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20-544 | Genesee Scientific | 5ml/Unit | EUR 242.32 |
Description: Cross-linked Beads, 4% |
Biotin Agarose |
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20-545 | Genesee Scientific | 10ml/Unit | EUR 456.66 |
Description: Cross-linked Beads, 4% |
Biochemical and molecular responses of maize (Zea mays L.) to 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH) diastereomers: Oxidative stress, DNA harm, antioxidant enzyme gene expression and variety of root exudates
The phytotoxicities of TBECH diastereomers to vegetation on the biochemical and molecular ranges have been investigated in a hydroponic research through the use of maize as a mannequin plant. The outcomes confirmed that TBECH might induce the manufacturing of two species of reactive oxygen species (ROS), O2•- and H2O2, in maize tissues. The buildup of ROS was the very best when maize was uncovered to β-TBECH. TBECH enhanced the phosphorylation of plant histone, and the contents of γ-H2AX in maize adopted the order β-TBECH > αβ-TBECH > γδ-TBECH > γ-TBECH.
Transcriptome profiling revealed that antioxidant enzyme genes (AEGs) have been over-expressed in maize when pressured by technical grade TBECH. The RT-PCR detection additional validated that three typical AEGs, together with CAT, SOD, and POD genes, have been time-dependent and selectively expressed underneath the affect of TBECH diastereomers. Molecular compositions of maize root exudates characterised by FT-ICR-MS have been considerably totally different among the many 4 teams of TBECH diastereomer therapies. TBECH diastereomers particularly affected the chemical variety and abundance of root exudates. New insights into the biochemical results of TBECH on vegetation are supplied on this work, which is useful to deepening the understanding of their stereo-selectivity
Synthesis of latest lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity analysis and molecular modeling
On this research, we synthesized 9 novel hybrids derived from d-xylose, d-ribose, and d-galactose sugars linked by a methylene chain with lophine. The compounds have been synthesized by a four-component response to afford the substituted imidazole moiety, adopted by the displacement response between sugar derivatives with an applicable <i>N</i>-alkylamino-lophine.
All of the compounds have been discovered to be the potent and selective inhibitors of BuChE exercise in mouse serum, with compound <b>9a</b> (a d-galactose spinoff) being probably the most potent inhibitor (IC<sub>50</sub> = 0.17 μM). In accordance with the molecular modeling outcomes, all of the compounds indicated that the lophine moiety existed on the backside of the BuChE cavity and shaped a T-stacking interplay with Trp231, a residue accessible completely within the BuChE cavity.
Noteworthily, just one compound exhibited exercise in opposition to AChE (<b>8b</b>; IC<sub>50</sub> = 2.75 μM). Furthermore, the <i>in silico</i> ADME predictions indicated that each one the hybrids formulated on this research have been drug-likely, orally out there, and capable of attain the CNS. Additional, <i>in vitro</i> research demonstrated that the 2 most potent compounds in opposition to BuChE (<b>8b</b> and <b>9a</b>) had no cytotoxic results within the Vero (kidney), HepG2 (hepatic), and C6 (astroglial) cell strains.
Cytogenetically seen inversions are shaped by a number of molecular mechanisms
Cytogenetically detected inversions are usually assumed to be copy quantity and phenotypically impartial occasions. Whereas non-allelic homologous recombination (NAHR) is believed to play a significant position, latest knowledge counsel the involvement of different molecular mechanisms in inversion formation. Utilizing a mix of short-read entire genome sequencing (WGS), 10X Genomics Chromium WGS, droplet digital PCR and array comparative genomic hybridization we investigated the genomic construction of 18 giant distinctive cytogenetically detected chromosomal inversions and achieved nucleotide decision of not less than one chromosomal inversion junction for 13/18 (72%).
Surprisingly, we noticed that seemingly copy quantity impartial inversions might be accompanied by copy-number achieve of as much as 350 kb and native genomic complexities (3/18, 17%). Within the remaining resolved inversions, the mutational signatures are per non-homologous end-joining (NHEJ) (8/13, 62%) and microhomology-mediated break-induced replication (MMBIR) (5/13, 38%). Our research signifies that short-read 30x protection WGS can detect a considerable fraction of chromosomal inversions.
Furthermore, replication-based mechanisms are liable for roughly 38% of these occasions resulting in a big proportion of inversions which can be really accompanied by extra copy-number variation probably contributing to the general phenotypic presentation of these sufferers. This text is protected by copyright. All rights reserved.
Agarose ME, Medium EEO |
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40100128-2 | Glycomatrix | 500 g | EUR 548.14 |
Agarose special, Medium EEO |
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MB175-100G | EWC Diagnostics | 1 unit | EUR 120.23 |
Description: Agarose special, Medium EEO |
Agarose special, Medium EEO |
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MB175-10G | EWC Diagnostics | 1 unit | EUR 20.25 |
Description: Agarose special, Medium EEO |
Agarose special, Medium EEO |
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MB175-1KG | EWC Diagnostics | 1 unit | EUR 971.54 |
Description: Agarose special, Medium EEO |
Agarose, medium EEO ?For electrophoresis |
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RM6249-100G | EWC Diagnostics | 1 unit | EUR 119.06 |
Description: Agarose, medium EEO ?For electrophoresis |
Agarose, medium EEO ?For electrophoresis |
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RM6249-10G | EWC Diagnostics | 1 unit | EUR 19.63 |
Description: Agarose, medium EEO ?For electrophoresis |
Agarose, medium EEO ?For electrophoresis |
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RM6249-1KG | EWC Diagnostics | 1 unit | EUR 1089.43 |
Description: Agarose, medium EEO ?For electrophoresis |
Agarose, medium EEO ?For electrophoresis |
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RM6249-25G | EWC Diagnostics | 1 unit | EUR 36.87 |
Description: Agarose, medium EEO ?For electrophoresis |
Agarose MR, Medium Resolution |
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40100132-1 | Glycomatrix | 100 g | EUR 284.99 |
Agarose MR, Medium Resolution |
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40100132-2 | Glycomatrix | 500 g | EUR 917.75 |
Agarose, Low EEO |
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40100152-1 | Glycomatrix | 50 g | EUR 75.92 |
Agarose, Low EEO |
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40100152-2 | Glycomatrix | 100 g | EUR 140.08 |
Agarose, Low EEO |
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40100152-3 | Glycomatrix | 500 g | EUR 446.01 |
Agarose, low EEO |
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GE0001-1 | Glentham Life Sciences | 1 | EUR 569.5 |
Agarose, low EEO |
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GE0001-100 | Glentham Life Sciences | 100 | EUR 102.7 |
Agarose, low EEO |
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GE0001-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
Agarose, low EEO |
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GE0001-1KG | Glentham Life Sciences | 1 kg | EUR 724.8 |
Agarose, low EEO |
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GE0001-25 | Glentham Life Sciences | 25 | EUR 39.4 |
Agarose, low EEO |
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GE0001-250 | Glentham Life Sciences | 250 | EUR 189.8 |
Agarose, low EEO |
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GE0001-250G | Glentham Life Sciences | 250 g | EUR 265.2 |
Agarose, low EEO |
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GE0001-25G | Glentham Life Sciences | 25 g | EUR 84 |
Agarose, low EEO |
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GE0001-5 | Glentham Life Sciences | 5 | EUR 19 |
Agarose, low EEO |
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GE0001-500 | Glentham Life Sciences | 500 | EUR 316.4 |
Agarose, low EEO |
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GE0001-500G | Glentham Life Sciences | 500 g | EUR 418.8 |
Agarose, low EEO |
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GE0001-5G | Glentham Life Sciences | 5 g | EUR 58.8 |
Agarose Low EEO |
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abx299901-100g | Abbexa | 100 µg | EUR 425 |
Agarose Low EEO |
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abx299901-20g | Abbexa | 20 µg | EUR 300 |
Agarose Low EEO |
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abx299901-50g | Abbexa | 50 µg | EUR 350 |
Agarose, High EEO |
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40100148-1 | Glycomatrix | 25 g | EUR 51.77 |
Agarose, High EEO |
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40100148-2 | Glycomatrix | 100 g | EUR 143.93 |
Agarose, high EEO |
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GE7747-1 | Glentham Life Sciences | 1 | EUR 660.6 |
Agarose, high EEO |
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GE7747-250 | Glentham Life Sciences | 250 | EUR 227.8 |
Agarose, high EEO |
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RM187-100G | EWC Diagnostics | 1 unit | EUR 174.08 |
Description: Agarose, high EEO |
Agarose, high EEO |
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RM187-10G | EWC Diagnostics | 1 unit | EUR 18.22 |
Description: Agarose, high EEO |
Agarose, high EEO |
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RM187-500G | EWC Diagnostics | 1 unit | EUR 748.81 |
Description: Agarose, high EEO |
Agarose High EEO |
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abx299903-100g | Abbexa | 100 µg | EUR 387.5 |
Agarose High EEO |
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abx299903-20g | Abbexa | 20 µg | EUR 275 |
Agarose High EEO |
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abx299903-50g | Abbexa | 50 µg | EUR 325 |
Agarose LE Low EEO |
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AXY1002 | Scientific Laboratory Supplies | PK10 | EUR 5152.05 |
Agarose B, Low EEO |
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AB0014 | Bio Basic | 50g | EUR 99.67 |
Agarose special, Low EEO |
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MB002-100G | EWC Diagnostics | 1 unit | EUR 38.61 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-10G | EWC Diagnostics | 1 unit | EUR 6.93 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-1KG | EWC Diagnostics | 1 unit | EUR 333.43 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-500G | EWC Diagnostics | 1 unit | EUR 185.23 |
Description: Agarose special, Low EEO |
Agarose special, Low EEO |
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MB002-50G | EWC Diagnostics | 1 unit | EUR 21.45 |
Description: Agarose special, Low EEO |
Agarose, special, Low EEO |
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RM273-100G | EWC Diagnostics | 1 unit | EUR 71.82 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-10G | EWC Diagnostics | 1 unit | EUR 11.64 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-25G | EWC Diagnostics | 1 unit | EUR 22.45 |
Description: Agarose, special, Low EEO |
Agarose, special, Low EEO |
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RM273-500G | EWC Diagnostics | 1 unit | EUR 374.99 |
Description: Agarose, special, Low EEO |
Agarose special, High EEO |
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MB176-100G | EWC Diagnostics | 1 unit | EUR 143.94 |
Description: Agarose special, High EEO |
Agarose special, High EEO |
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MB176-10G | EWC Diagnostics | 1 unit | EUR 14.92 |
Description: Agarose special, High EEO |
Agarose special, High EEO |
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MB176-500G | EWC Diagnostics | 1 unit | EUR 383.85 |
Description: Agarose special, High EEO |
Agarose, Ultrapure, Low EEO |
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MB229-100G | EWC Diagnostics | 1 unit | EUR 110.64 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-1KG | EWC Diagnostics | 1 unit | EUR 707.74 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-500G | EWC Diagnostics | 1 unit | EUR 442.58 |
Description: Agarose, Ultrapure, Low EEO |
Agarose, Ultrapure, Low EEO |
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MB229-50G | EWC Diagnostics | 1 unit | EUR 58.16 |
Description: Agarose, Ultrapure, Low EEO |
Agarose LE Low EEO - PK10 |
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AXY1000 | Scientific Laboratory Supplies | PK10 | EUR 2560.95 |
DiagAg™ Butyl Agarose Weak Hydrophobic Medium, 4% Crosslinked, 45-165 µm |
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DAG-YS23-09 | Creative Diagnostics | 25 mL | EUR 960 |
DiagAg™ Butyl Agarose Weak Hydrophobic Medium, 6% Crosslinked, 24-45 µm |
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DAG-YS23-25 | Creative Diagnostics | 25 mL | EUR 960 |
DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm |
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DAG-YS23-27 | Creative Diagnostics | 25 mL | EUR 850 |
Agarose, low EEO, GlenBiol, suitable for molecular biology |
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GE6258-100G | Glentham Life Sciences | 100 g | EUR 217.2 |
DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, Low Capacity |
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DAG-YS23-28 | Creative Diagnostics | 25 mL | EUR 850 |
DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, High Capacity |
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DAG-YS23-29 | Creative Diagnostics | 25 mL | EUR 850 |
Agarose, low EEO, GlenBiol™, suitable for molecular biology |
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GE6258-100 | Glentham Life Sciences | 100 | EUR 150.4 |
Agarose, low EEO, GlenBiol™, suitable for molecular biology |
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GE6258-25 | Glentham Life Sciences | 25 | EUR 60.1 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT |
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AGR-LE-100 | CORNING | 1/pk | EUR 201.6 |
Description: Bioscience Mol Bio; Agarose |
Agarose: high melting temperature/medium resolution for all of your standard DNA applications 500 g - EACH |
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DD4905009 | Scientific Laboratory Supplies | EACH | EUR 1391.85 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 500G/UNIT, 10 UNITS PER CASE |
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AGR-LE-5001 | CORNING | 1/pk | EUR 3669.6 |
Description: Bioscience Mol Bio; Agarose |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT, 10 UNITS PER CASE |
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AGR-LE-1001 | CORNING | 1/pk | EUR 926.4 |
Description: Bioscience Mol Bio; Agarose |
Agarose |
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G060-1 | ABM | 100 g | EUR 185 |
Description: Agarose, derived from agar, is a polymeric cross-linked polysaccharide that is mainly used in gel electrophoresis. The lattice bonds formed in the gel allow proteins of different sizes to travel at different speeds down the gel. |
Agarose |
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G060-2 | ABM | 500 g | EUR 415 |
Description: Agarose, derived from agar, is a polymeric cross-linked polysaccharide that is mainly used in gel electrophoresis. The lattice bonds formed in the gel allow proteins of different sizes to travel at different speeds down the gel. |
Agarose |
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A12140 | Pfaltz & Bauer | 5G | EUR 113.97 |
Agarose |
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20-abx098147 | Abbexa |
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Agarose |
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20-abx186369 | Abbexa |
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