Molecular Engineering via Controlling Structura

phase1tox

Molecular Engineering by way of Controlling Structural Deformation for Extremely Environment friendly Ultralong Natural Phosphorescence

 It is a gigantic problem to attain the extremely environment friendly natural room-temperature phosphorescence (RTP) with lengthy lifetime. Right here we demonstrated that by bridging the carbazole and halogenated phenyl ring with methylene linker, a kind of RTP phosphors CzBX (X = Cl, Br) exhibits excessive phosphorescence effectivity ( Ф Ph ), as much as 38% for CzBBr with a lifetime of 220 ms, which is far increased than that of compounds CzPX (X = Cl, Br) with C-N bond as a linker ( Ф Ph < 1%).

Single crystal evaluation and theoretical calculations revealed that, within the crystal part, the intermolecular π-Br interplay accelerates the intersystem crossing course of, whereas tetrahedron-like construction induced by sp Three methylene linker restrains the nonradiative decay channel, resulting in the excessive phosphorescence effectivity in CzBBr. This analysis not solely paves a brand new highway for reaching extremely environment friendly and long-lived RTP supplies but in addition expands the purposes in anti-counterfeiting or information encryption

phase1tox
phase1tox

Agarose B, Low EEO

AB0014 50g
EUR 83.06

Agarose, Low melting gel

AB0015 10g
EUR 80.45

HiQTM Low Melting Agarose

A0223-002 25g
EUR 286

HiQTM Low Melting Agarose

A0223-010 100g
EUR 583

Agarose GPG/LMP low melt

A2501-100000 100 g
EUR 425
Description: Agarose has a wide range of physical, chemical and thermal stability, because of its greatest gelling ability that it acquires wide applications in biotechnology [2], such as agarose gel electrophoresis, protein purification, solid culture media, motility assays.

Agarose GPG/LMP low melt

A2501-25000 25 g
EUR 154
Description: Agarose has a wide range of physical, chemical and thermal stability, because of its greatest gelling ability that it acquires wide applications in biotechnology [2], such as agarose gel electrophoresis, protein purification, solid culture media, motility assays.

Agarose II, Low Gelling Temperature

CH002 25 g
EUR 229

Agarose II, Low Gelling Temperature

CH003 100 g
EUR 438

HyAgarose? LM Agarose, Low Melting, 100g

R9012LM-100g
EUR 377

HyAgarose? LM Agarose, Low Melting, 10g

R9012LM-10g
EUR 100

HyAgarose? LM Agarose, Low Melting, 500g

R9012LM-500g
EUR 1518

HyAgarose? LM Agarose, Low Melting, 50g

R9012LM-50g
EUR 219

Individual Reaction Mix 6

G065-6 200 reactions
EUR 167

Agarose, low EEO, GlenBiol, suitable for molecular biology

GE6258-100G 100 g
EUR 181

Mouse IL-6 Recombinant Protein

R00102-6 5ug/vial
EUR 259
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Mouse IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Tissue Culture Plate, 6 Well

TCP20-6 1 UNIT
EUR 53.48

Random Nanofibers 6 Well Plate

3D00006-6 700 nm-PCLs
EUR 93

Aligned Nanofibers 6 Well Plate

3D00012-6 700 nm-PCLs
EUR 97

pLenti-CLDN1 shRNA-6 Plasmid

PVTBAV04867-6 2 ug
EUR 356

Aligned Nanofibers 6 Well Plate Inserts

3D00016-6 700 nm-PCLs
EUR 98

Agarose

abx082006-100g 100 g
EUR 244

Agarose

abx082007-100g 100 g
EUR 258

Agarose

abx082008-100g 100 g
EUR 230

Agarose

20-abx098147
  • EUR 217.00
  • EUR 105.00
  • 100 g
  • 1 g

Agarose

20-abx186369
  • EUR 509.00
  • EUR 300.00
  • 100 g
  • 25 g

Agarose

G060-1 100 g
EUR 176

Agarose

G060-2 500 g
EUR 369

Agarose

Z5050007 500 g
EUR 615
Description: None pays much attention to the agarose until your gel comes out all with waves and uneven thickness. Or even worse, the gel comes out all good only to start melting while you are running the electrophoresis wasting you precious samples. Save yourself some trouble and get our agarose which will provide you with excellent gel quality every time.

Agarose

Z5050013 100 g
EUR 189
Description: None pays much attention to the agarose until your gel comes out all with waves and uneven thickness. Or even worse, the gel comes out all good only to start melting while you are running the electrophoresis wasting you precious samples. Save yourself some trouble and get our agarose which will provide you with excellent gel quality every time.

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 6 vials)

M1040-6
EUR 1300

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 6 vials)

M1041-6
EUR 1572

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 6 vials)

M1042-6
EUR 1300

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 6 vials)

M1043-6
EUR 1572

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials)

M1044-6
EUR 1289

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 6 vials)

M1045-6
EUR 1572

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 6 vials)

M1046-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 6 vials)

M1047-6
EUR 1621

ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 6 vials)

M1054-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 6 vials)

M1055-6
EUR 1616

AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT

AGR-LE-100 1/pk
EUR 168
Description: Bioscience Mol Bio; Agarose

Protein A-Agarose High-Binding 6% Highly Crosslinked

P9301-005 5ml
EUR 228

Protein A-Agarose High-Binding 6% Highly Crosslinked

P9301-010 10ml
EUR 347

Protein A-Agarose High-Binding 6% Highly Crosslinked

P9301-050 50ml
EUR 1357

Protein A-Agarose High-Binding 6% Highly Crosslinked

P9301-100 100ml
EUR 2413

6% B Agarose Bead Fine (20-50 µm)

A-1060F-1000 1 l
EUR 721

6% B Agarose Bead Fine (20-50 µm)

A-1060F-250 250 ml
EUR 243

6% B Agarose Bead Fine (20-50 µm)

A-1060F-500 500 ml
EUR 398

6% B Agarose Bead Standard (50-150 µm)

A-1060S-1000 1 l
EUR 482

6% B Agarose Bead Standard (50-150 µm)

A-1060S-10000 10 l Ask for price

6% B Agarose Bead Standard (50-150 µm)

A-1060S-500 500 ml
EUR 277

6% BCL Agarose Bead Fine (20-50 µm)

A-1061F-1000 1 l
EUR 772

6% BCL Agarose Bead Fine (20-50 µm)

A-1061F-250 250 ml
EUR 280

6% BCL Agarose Bead Fine (20-50 µm)

A-1061F-500 500 ml
EUR 446

6% BCL Agarose Bead Standard (50-150 µm)

A-1061S-1000 1 l
EUR 546

6% BCL Agarose Bead Standard (50-150 µm)

A-1061S-10000 10 l Ask for price

6% BCL Agarose Bead Standard (50-150 µm)

A-1061S-500 500 ml
EUR 312

ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 6 vials)

M1048-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 6 vials)

M1049-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 6 vials)

M1050-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 6 vials)

M1051-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 6 vials)

M1052-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 6 vials)

M1053-6
EUR 1572

ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 6 vials)

M1058-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 6 vials)

M1059-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 6 vials)

M1060-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 6 vials)

M1061-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 6 vials)

M1064-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 6 vials)

M1065-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 6 vials)

M1066-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 6 vials)

M1067-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 6 vials)

M1070-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (1090 µg, B16F10 cell line, 6 vials)

M1071-6
EUR 1616

BEAKER,1L,PLASTIC,LOW FORM,PP,6/6

1000P-1L 6/pk
EUR 63
Description: Reusable Plastics; Resuable Beakers

BEAKER,250ML,PLASTIC,LOW FORM,PP,6/6

1000P-250 6/pk
EUR 46
Description: Reusable Plastics; Resuable Beakers

BEAKER,2L,PLASTIC,LOW FORM,PP,6/6

1000P-2L 6/pk
EUR 101
Description: Reusable Plastics; Resuable Beakers

BEAKER,400ML,PLASTIC,LOW FORM,PP,6/6

1000P-400 6/pk
EUR 50
Description: Reusable Plastics; Resuable Beakers

BEAKER,600ML,PLASTIC,LOW FORM,PP,6/6

1000P-600 6/pk
EUR 56
Description: Reusable Plastics; Resuable Beakers

ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 6 vials)

M1062-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 6 vials)

M1063-6
EUR 1616

ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 6 vials)

M1068-6
EUR 1306

ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 6 vials)

M1069-6
EUR 1616

Agarose A

D0012 50g
EUR 80.45

Agarose L.M.P

20-abx082386
  • EUR 272.00
  • EUR 217.00
  • 10 g
  • 5 g

Agarose M

AB0013 50g
EUR 76.1

Agarose StandardRoomTemperature

FYA002-100G 100 g Ask for price

Agarose StandardRoomTemperature

FYA002-500G 500 g Ask for price

Agarose Tablets

BA50201 100pcs
EUR 109
Description: Ultrapure agarose for separation and further analysis of PCR products.

Agarose, Sepro

A0224-010 100g
EUR 219

Agarose, Sepro

A0224-020 200g
EUR 286

Agarose, Sepro

A0224-050 500g
EUR 435

Agarose LE

A-1270-100 100 g
EUR 116

Agarose LE

A-1270-500 500 g
EUR 291

Agarose HR

A-1280-100 100 g
EUR 183

Agarose HR

A-1280-500 500 g
EUR 685

Mg 2+-Dependent Methyl Switch by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Research

 

Mg2+ is required for the catalytic exercise of TrmD, a bacteria-specific methyltransferase that’s made up of a protein topological knot-fold, to synthesize methylated m1G37-tRNA to help life. Nevertheless, neither the situation of Mg2+ within the construction of TrmD nor its function within the catalytic mechanism is understood. Utilizing molecular dynamics (MD) simulations, we determine a believable Mg2+ binding pocket throughout the lively web site of the enzyme, whereby the ion is coordinated by two aspartates and a glutamate.

On this place, Mg2+ moreover interacts with the carboxylate of a methyl donor cofactor S-adenosylmethionine (SAM). The computational outcomes are validated by experimental mutation research, which reveal the significance of the Mg2+-binding residues for the catalytic exercise. The presence of Mg2+ within the binding pocket induces SAM to undertake a singular bent form required for the methyl switch exercise and causes a structural reorganization of the lively web site.

Quantum mechanical calculations present that the methyl switch is energetically possible solely when Mg2+ is sure within the place revealed by the MD simulations, demonstrating that its operate is to align the lively web site residues throughout the topological knot-fold in a geometry optimum for catalysis. The obtained insights present the chance for creating a technique of antibacterial drug discovery based mostly on focusing on of Mg2+-binding to TrmD.

Molecular mechanisms of FasL-mediated ‘reverse-signaling’

 Effector lymphocytes, together with NK and T cells, categorical FasL. Expression of Fas, the receptor for FasL in tumor cells, renders them vulnerable to NK and T cell-mediated killing. The purposeful relevance of FasL in initiating dying indicators in tumor cells is well-characterized. Nevertheless, the cytoplasmic interacting companions and the potential signaling pathways downstream of FasL are removed from absolutely outlined. FasL possesses an 81 amino acid lengthy cytoplasmic tail with a number of distinctive recruitment motifs.

We predict a number of interdependent signaling complexes kind the core of the ‘reverse signaling’ downstream of FasL. A direct interplay between the proline-rich area of FasL and the SH3 area of PI(3)Ok-p85α initiates the primary pathway. This cascade helps FasL to hyperlink to PLC-γ2 by way of PIP3 or the Akt-dependent activation of mTOR complexes. Independently, a GRB2/GADs-binding PXXP cytoplasmic motif of FasL can provoke a Ras-GTP-dependent PAK1→C-Raf→MEK1/2→ERK1/2 activation.

FasL can recruit Fyn by way of the proline-rich area resulting in the recruitment of ADAP. By means of its capability to immediately work together with Carma1 and TAK1, ADAP initiates the formation of the Carma1/Bcl10/Malt1-based CBM signalosome that’s primarily answerable for inflammatory cytokine manufacturing. Right here, we discover the conserved cytoplasmic domains of FasL, the potential signaling molecules that work together, and the purposeful downstream penalties throughout the effector lymphocytes to outline the FasL-mediated ‘reverse signaling’

Molecular and organic characterization of Chilli leaf curl virus and related betasatellite infecting Cucurbita maxima in Oman

 Throughout a survey in February 2016, leaf curl illness signs have been witnessed in Cucurbita maxima crops in Al-Batina business farm in Oman. Signs exhibited have been attribute of begomovirus an infection as leaf curling, yellowing, and shade breaking adopted by mosaic sample. The transmission electron microscopy confirmed the presence of typical twinned geminate typical of Geminate virus particles.

Rolling circle amplification (RCA) was employed to characterize the unknown causal agent of C. maxima illness. In molecular identification RCA produced practically 2.eight and 1.four kb DNA molecules akin to begomovirus and satellite tv for pc molecules, cloned and sequenced them. In Blast, species demarcation instrument and phylogenetic evaluation revealed the begomovirus and satellite tv for pc isolates have been decided as Chilli leaf curl virus (ChLCV) and tomato leaf curl betasatellite (ToLCB).

In organic evaluation by agrobacterium mediated inoculation, ChLCV displayed upward leaf curling and vein swelling signs in Nicotiana benthamiana crops; nonetheless, in presence of ToLCB enhanced downward leaf curling and crumpling signs have been revealed. This examine gives the primary proof that ChLCV and ToLCB prompted leaf curl illness of C. maxima in Oman.

500 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS

46-000-CV 500 mL/pk
EUR 106
Description: Media Catalog; Sterile Wi-Fi Qual, Cell

Molecular Weight Marker

abx098957-15ul 15 ul
EUR 105

Agarose, Molecular Grade

BIO-41025 500g Ask for price

Agarose, Molecular Grade

BIO-41026 100g Ask for price

BCIP (Molecular Biology Grade)

CE108 250 mg
EUR 63

BCIP (Molecular Biology Grade)

CE109 1 g
EUR 90

CHAPS (Molecular Biology Grade)

CE114 1 g
EUR 55

CHAPS (Molecular Biology Grade)

CE115 5 g
EUR 131

CHAPS (Molecular Biology Grade)

CE116 25 g
EUR 410

DAPI (Molecular Biology Grade)

CE117 5 mg
EUR 60

DAPI (Molecular Biology Grade)

CE118 25 mg
EUR 133

DAPI (Molecular Biology Grade)

CE119 100 mg
EUR 319

Dimethylsulfoxide (Molecular Biology Grade)

CE120 100 ml
EUR 55

Dimethylsulfoxide (Molecular Biology Grade)

CE121 500 ml
EUR 92

DTT (Molecular Biology Grade)

CE131 5 g
EUR 78

DTT (Molecular Biology Grade)

CE132 10 g
EUR 111

DTT (Molecular Biology Grade)

CE133 25 g
EUR 203

Glycine (Molecular Biology Grade)

CE158 1 kg
EUR 70

Glycine (Molecular Biology Grade)

CE159 5 kg
EUR 190

HEPES (Molecular Biology Grade)

CE171 100 g
EUR 82

HEPES (Molecular Biology Grade)

CE172 500 g
EUR 224

HEPES (Molecular Biology Grade)

CE173 1 kg
EUR 354

Lysozyme (Molecular Biology Grade)

CE188 1 g
EUR 59

Lysozyme (Molecular Biology Grade)

CE189 10 g
EUR 206

NAD (Molecular Biology Grade)

CE196 1 g
EUR 60

NAD (Molecular Biology Grade)

CE197 5 g
EUR 138

NBT (Molecular Biology Grade)

CE209 1 g
EUR 103

NBT (Molecular Biology Grade)

CE210 5 g
EUR 300

Tris (Molecular Biology Grade)

CE237 500 g
EUR 89

Tris (Molecular Biology Grade)

CE238 1 kg
EUR 128

Tris (Molecular Biology Grade)

CE239 5 kg
EUR 446

Tween20 (Molecular Biology Grade)

CE242 1 l
EUR 89

Water (Molecular Biology Grade)

CE243 500 ml
EUR 52

Water (Molecular Biology Grade)

CE244 1 l
EUR 56

Chitosan, low molecular weight

GC9009-50G 50 g
EUR 76

Chitosan, low molecular weight

GC9009-100G 100 g
EUR 118

Ovalbumin, purified

O705084 1g
EUR 67.4

Purified GFP

AG45-0205-Z 0.1 mg
EUR 228

Ammonium sulfate (Molecular Biology Grade)

CE105 250 g
EUR 46

Ammonium sulfate (Molecular Biology Grade)

CE106 1 kg
EUR 60

Ammonium sulfate (Molecular Biology Grade)

CE107 5 kg
EUR 128

Bis-Acrylamid (Molecular Biology Grade)

CE110 50 g
EUR 79

Bis-Acrylamid (Molecular Biology Grade)

CE111 250 g
EUR 216

Formamide deionized (Molecular Biology Grade)

CE145 500 ml
EUR 73

Formamide deionized (Molecular Biology Grade)

CE146 1 l
EUR 100

Glycerol 87 % (Molecular Biology Grade)

CE154 1 l
EUR 78

Glycerol waterfree (Molecular Biology Grade)

CE155 500 ml
EUR 65

Glycerol waterfree (Molecular Biology Grade)

CE156 1 l
EUR 85

Glycerol waterfree (Molecular Biology Grade)

CE157 2.5 l
EUR 142

Guanidine - Hydrochloride (Molecular Biology Grade)

CE160 100 g
EUR 78

Guanidine - Hydrochloride (Molecular Biology Grade)

CE161 250 g
EUR 128

Guanidine - Hydrochloride (Molecular Biology Grade)

CE162 500 g
EUR 194

Guanidine - Hydrochloride (Molecular Biology Grade)

CE163 1 kg
EUR 294

Guanidine Thiocyanate (Molecular Biology Grade)

CE164 100 g
EUR 72

Guanidine Thiocyanate (Molecular Biology Grade)

CE165 500 g
EUR 160

Guanidine Thiocyanate (Molecular Biology Grade)

CE166 1 kg
EUR 256

Urea Crystalline (Molecular Biology Grade)

CE167 1 kg
EUR 60

Urea Crystalline (Molecular Biology Grade)

CE168 5 kg
EUR 151

MOPS buffer (Molecular Biology Grade)

CE194 100 g
EUR 85

MOPS buffer (Molecular Biology Grade)

CE195 250 g
EUR 141

Sodium chloride (Molecular Biology Grade)

CE205 500 g
EUR 52

Sodium chloride (Molecular Biology Grade)

CE206 1 kg
EUR 59

Sodium chloride (Molecular Biology Grade)

CE207 5 kg
EUR 103

D(+)-Sucrose (Molecular Biology Grade)

CE224 500 g
EUR 56

D(+)-Sucrose (Molecular Biology Grade)

CE225 1 kg
EUR 70

D(+)-Sucrose (Molecular Biology Grade)

CE226 5 kg
EUR 173

Tris - Hydrochloride (Molecular Biology Grade)

CE234 250 g
EUR 83

Tris - Hydrochloride (Molecular Biology Grade)

CE235 500 g
EUR 120

Tris - Hydrochloride (Molecular Biology Grade)

CE236 1 kg
EUR 186

TritonX-100 (Molecular Biology Grade)

CE240 500 ml
EUR 56

TritonX-100 (Molecular Biology Grade)

CE241 1 l
EUR 66

Urea, suitable for molecular biology

GE1210-1KG 1 kg
EUR 89

Urea, suitable for molecular biology

GE1210-500G 500 g
EUR 64

Tween 20, Molecular Biology Grade

T9100-010 100ml
EUR 72

Tween 20, Molecular Biology Grade

T9100-050 500ml
EUR 111

Tween 20, Molecular Biology Grade

T9100-100 1L
EUR 134

Water, Ultrapure Molecular Biology Grade

41024-4L 4L
EUR 121
Description: Minimum order quantity: 1 unit of 4L

Sacsin Molecular Chaperone (SACS) Antibody

20-abx334098
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Proteinase K, Recombinant, Molecular Grade

9210-100
EUR 120

Proteinase K, Recombinant, Molecular Grade

9210-10G
EUR 2643

Proteinase K, Recombinant, Molecular Grade

9210-1G
EUR 338

Proteinase K, Recombinant, Molecular Grade

9210-500
EUR 262

Proteinase K, Recombinant, Molecular Grade

9210-50G Ask for price

Purified, Human HEMOGLOBIN

DAG109 20mg
EUR 907

AFP Antigen (Purified)

E62C00201 20ug
EUR 382

CEA Antigen (Purified)

E62C01001 20ug
EUR 382

Myoglobin antigen (Purified)

E64C00401 100ug
EUR 375

Myoglobin antigen (Purified)

E64C00401a 20ug
EUR 343

Anti-Cytokeratins Purified

11-108-C025 0.025 mg
EUR 99

Anti-Cytokeratins Purified

11-108-C100 0.1 mg
EUR 158

Anti-MFG Purified

11-113-C025 0.025 mg
EUR 90

Anti-MFG Purified

11-113-C100 0.1 mg
EUR 140

Anti-p53 Purified

11-114-C025 0.025 mg
EUR 104

Anti-p53 Purified

11-114-C100 0.1 mg
EUR 167

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